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Allele : Egfr<tm1.1Grj> epidermal growth factor receptor; targeted mutation 1.1, Gibbes R Johnson
Primary Identifier  MGI:7574230 Allele Type  Targeted
Gene  Egfr Transmission  Germline
Strain of Origin  129S6/SvEvTac Is Recombinase  false
Is Wild Type  false
molecularNote  Lysine codon 747 (AAG) in exon 19 was changed to methionine (ATG) (p.K747M) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 18. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation renders the encoded peptide kinase-dead.
  • mutations:
  • Single point mutation
  • synonyms:
  • KI EGFR,
  • KI EGFR
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

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Trail: Allele




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