Primary Identifier | MGI:107795 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 15381 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in pronucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human HNRNPC (heterogeneous nuclear ribonucleoprotein C). PHENOTYPE: Mice homozygous for a gene trapped allele fail to undergo gastrulation, appear to arrest at the egg cylinder stage, and are resorbed at various times thereafter. [provided by MGI curators] |