| First Author | Duran-Reynals ML | Year | 1978 |
| Journal | J Exp Med | Volume | 147 |
| Issue | 2 | Pages | 459-69 |
| PubMed ID | 624906 | Mgi Jnum | J:25394 |
| Mgi Id | MGI:73123 | Doi | 10.1084/jem.147.2.459 |
| Citation | Duran-Reynals ML, et al. (1978) The genetic basis of susceptibility to leukemia induction in mice by 3-methylcholanthrene applied percutaneously. J Exp Med 147(2):459-69 |
| abstractText | Susceptibility to leukemia induction in mice by skin painting with 3-methylcholanthrene (MCA) is strain-specific, occurring only in strains relatively resistant to MCA-induced skin tumors. The Ah locus, which has a dominant allele (Ahb) for inducibility of the aryl hydrocarbon hydroxylase (AHH) enzyme system and a recessive allele (Ahd) for noninducibility, appears to be the major determinant of this trait. MCA-painted mice of strains and crosses carrying the Ahb allele usually show a high incidence of skin tumors (papillomas which may evolve into malignant tumors) and little or no leukemia, whereas in mice homozygous for the Ahd allele the treatment usually induces a high incidence of leukemia and few or no skin tumors. Among mice of a segregating backcross generation including both Ahb/Ahd heterozygotes and Ahd homozygotes, the occurrence of skin tumors was correlated directly with AHH inducibility and inversely with the leukemic response. Mice of Ahb strains with a high level of endogenous murine leukemia (MuLV) expression (C58, PL) show a much weaker skin tumor response than expected but no increase in leukemia incidence, and this observation tends to confirm the previous finding that MuLV infection of mice of low-MuLV strains results in reduced susceptibility to MCA tumorigenesis. |
