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Comment :

Type  MGI:General Description  all homozygotes display an acrania/meroanencephaly phenotype mutant pups delivered by caesarean section at E18.5 are alive with exposed and degenerating brain tissue, suggesting that lack of brain tissue is due to cannibalism by the mother folic acid treatment suppresses the development of the acrania/meroanencephaly phenotype but does not rescue the brain defects that compromise neonatal viability