Primary Identifier | MGI:1933196 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 81000 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including ATP binding activity; ATP hydrolysis activity; and transcription coregulator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Is expressed in central nervous system; embryo; limb; and neural ectoderm. Orthologous to human RAD54L2 (RAD54 like 2). PHENOTYPE: Homozygous null embryos show delayed growth, reduced cell proliferation, increased apoptosis and die by E11.5. At E9.5-E10.5, most major organs are smaller and the neural tube is shrunk in some cases. Mutant MEFs cease to grow after 2-3 passages showing increased apoptosis and reduced DNA synthesis. [provided by MGI curators] |