| First Author | Krishna G | Year | 2001 |
| Journal | Am J Pathol | Volume | 158 |
| Issue | 3 | Pages | 997-1004 |
| PubMed ID | 11238047 | Mgi Jnum | J:67896 |
| Mgi Id | MGI:1931669 | Doi | 10.1016/S0002-9440(10)64046-1 |
| Citation | Krishna G, et al. (2001) Pg490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am J Pathol 158(3):997-1004 |
| abstractText | In this study we evaluate the antifibrotic properties of PG-490-88, a water-soluble derivative of triptolide. Triptolide is an oxygenated diterpene that is derived from a traditional Chinese herb that has potent immunosuppressive and antitumor activity. We used the intratracheal bleomycin mouse model and found that PG490-88 inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. PG490-88 also markedly reduced the number of myofibroblasts in the bleomycin treatment group. An enzyme-linked immunosorbent assay of transforming growth factor (TGF)-beta in the bronchoalveolar lavage fluid showed a significant decrease in TGF-beta in the PG490-88-treated groups compared to the bleomycin-treated group. Additionally, triptolide blocked bleomycin-induced increase in TGF-beta mRNA in cultured normal human lung fibroblasts. The efficacy of PG490-88 when administered late after bleomycin installation suggests a potential role in the treatment of idiopathic pulmonary fibrosis. |
