| First Author | Russ AP | Year | 1992 |
| Journal | Biochim Biophys Acta | Volume | 1132 |
| Issue | 3 | Pages | 329-31 |
| PubMed ID | 1358203 | Mgi Jnum | J:38707 |
| Mgi Id | MGI:86089 | Doi | 10.1016/0167-4781(92)90172-v |
| Citation | Russ AP, et al. (1992) Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase. Biochim Biophys Acta 1132(3):329-31 |
| abstractText | Cytosolic 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase (E.C. 4.1.3.5) is a highly regulated enzyme involved in isoprenoid biosynthesis and therefore a potential target for cholesterol-lowering drugs. Up to now, primary structure data have only been available for chicken, rat and hamster HMG-CoA synthase. Using in vitro amplification and direct sequencing, we have determined the nucleotide sequence of the coding region of the human cytosolic 3-hydroxy-3-methylglutaryl CoA synthase cDNA. |
