| First Author | Goh BC | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 360 |
| Issue | 4 | Pages | 828-33 |
| PubMed ID | 17624301 | Mgi Jnum | J:123508 |
| Mgi Id | MGI:3718752 | Doi | 10.1016/j.bbrc.2007.06.136 |
| Citation | Goh BC, et al. (2007) Food entrainment of circadian gene expression altered in PPARalpha(-/-) brown fat and heart. Biochem Biophys Res Commun 360(4):828-33 |
| abstractText | The circadian clock is subject to food entrainment. Since PPARalpha exhibits a circadian expression profile, we hypothesized that PPARalpha deficiency would alter the food entrainable response of adipose, cardiac, and liver tissues. Wild-type and PPARalpha null mice were compared under ad libitum or restricted food access for the expression of circadian transcription factor-encoding mRNAs. Temporally restricted food access caused between a mean 5.8-11.5h phase shift in the expression profiles of the circadian genes Bmal1, Per3, and Rev-erbalpha in all tissues of control mice. In contrast, these same conditions phase shifted the circadian genes in tissues of PPARalpha null mice between a mean of 10.8-14.2h with amplitude attenuation. The food entrained phase shifts in the brown adipose and cardiac tissue circadian transcription factors of the PPARalpha null mice were prolonged significantly relative to wild-type controls. Likewise, PPARalpha responsive genes in the livers of PPARalpha null mice exhibited a significantly prolonged phase shift relative to control mice. These findings confirm and extend recent observations in the literature. |
