| Primary Identifier | MGI:891999 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 110532 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable adenosine deaminase activity; double-stranded RNA binding activity; and identical protein binding activity. Involved in adenosine to inosine editing. Acts upstream of or within several processes, including motor neuron apoptotic process; nerve development; and spinal cord ventral commissure morphogenesis. Located in nucleus and synapse. Is expressed in several structures, including arterial blood vessel; brain; genitourinary system; heart; and sensory organ. Used to study amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1). PHENOTYPE: Homozygous mutation of this gene results in progressive seizure susceptibility and death within 20 days of age. Mice homozygous for a conditional allele activated in neurons exhibit motor neuron degeneration, motor function abnormalities, and premature death. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
