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Allele : Apobec3<Rfv3-r> apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; recovery from Friend virus 3, resistant

Primary Identifier  MGI:3809767 Gene  Apobec3
Inheritance Mode  Dominant Strain of Origin  multiple strains
Is Recombinase  false Is Wild Type  false
molecularNote  This gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This dominant allele is found in C57BL/6J, C57BL/10, and 129P2/OlaHsd strains and allows for recovery from both viremia and leukemia in H2b mice. Recovery from viremia only is seen in H2a mice. This allele produces a full length mRNA transcript (including exon 2) that encodes for a protein with potent anti-viral activity.
  • mutations: