| First Author | Nakamura Y | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 23 | Pages | 4076-81 |
| PubMed ID | 23085393 | Mgi Jnum | J:191242 |
| Mgi Id | MGI:5461287 | Doi | 10.1016/j.febslet.2012.10.009 |
| Citation | Nakamura Y, et al. (2012) SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice. FEBS Lett 586(23):4076-81 |
| abstractText | We identified urate oxidase (UOX) as a target of SIRT5 by comparing mitochondrial proteins in livers of SIRT5-overexpressing transgenic (SIRT5 Tg) and wild-type mice by using two-dimensional electrophoresis. Acetylation levels of UOX in liver of SIRT5 Tg mice were approximately half of those in wild-type mice, and UOX activity was significantly increased. Invitro-synthesized UOX protein was acetylated when incubated with mitochondria from wild-type mice liver but the levels were less when incubated with those from SIRT5 Tg mice liver. These results suggest that SIRT5 activates UOX through deacetylation in mouse liver mitochondria. |
