First Author | Caras IW | Year | 1985 |
Journal | J Biol Chem | Volume | 260 |
Issue | 11 | Pages | 7015-22 |
PubMed ID | 2581962 | Mgi Jnum | J:7868 |
Mgi Id | MGI:56337 | Doi | 10.1016/s0021-9258(18)88881-0 |
Citation | Caras IW, et al. (1985) Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino acid sequence homology with Escherichia coli and herpesvirus ribonucleotide reductases. J Biol Chem 260(11):7015-22 |
abstractText | We have isolated and sequenced overlapping cDNA clones containing the entire coding region of mouse ribonucleotide reductase subunit M1. The coding region comprises 2.4 kilobases and predicts a polypeptide of 792 amino acids (Mr 90,234) which shows striking homology with ribonucleotide reductases from Escherichia coli and the herpesviruses, Epstein-Barr virus and herpes simplex virus. The homologies reveal three domains: an N-terminal domain common to the mammalian and bacterial enzymes, a C-terminal domain common to the mammalian and viral ribonucleotide reductases, and a central domain common to all three. We speculate on the functional basis of this conservation. |