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Allele : Camk2a<tm1.1Oyam> calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1.1, Yoko Yamagata

Primary Identifier  MGI:3849851 Allele Type  Targeted
Gene  Camk2a Transmission  Germline
Strain of Origin  (C57BL/6NCrlj x CBA/JNCrlj)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 2 was replaced with one in which an A to G transition results in an amino acid substitution of arginine for lysine at position 42 (K42R). This mutation abolishes the kinase activity of the protein product, as determined by enzymatic assays. A floxed neo cassette inserted downstream of exon 2 was removed by transient cre expression in ES cells.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • CaMKIIalpha(K42R),
  • CaMKIIalpha(K42R)
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

4 Carried By

Trail: Allele

0 Driven By

8 Publication categories

Trail: Allele