| First Author | Desch M | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 18 | Pages | 3979-84 |
| PubMed ID | 20691687 | Mgi Jnum | J:164397 |
| Mgi Id | MGI:4833756 | Doi | 10.1016/j.febslet.2010.07.059 |
| Citation | Desch M, et al. (2010) Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I. FEBS Lett 584(18):3979-84 |
| abstractText | We analysed the function and intracellular signalling of the cyclic pyrimidinic nucleotide cCMP. The membrane-permeable cCMP analogue dibutyryl-cCMP mediated mouse aorta relaxation. cCMP activated purified cGMP-dependent protein kinase (cGK) Ialpha and Ibeta and stimulated cGK in aorta lysates. cCMP-induced relaxation was abolished in cGKI-knockout tissue. Additionally, deletion of inositol-trisphosphate receptor associated cGKI substrate (IRAG) suppressed cCMP-mediated relaxation. Signalling of cCMP via cGKI/IRAG appears to be of broader physiological importance because cCMP-mediated inhibition of platelet aggregation was absent in cGKI- and IRAG-deficient platelets. These results demonstrate that cCMP acts as intracellular messenger molecule, most unexpectedly utilizing the cGMP signal transduction pathway. |
