| First Author | Kohler S | Year | 2001 |
| Journal | Biochim Biophys Acta | Volume | 1519 |
| Issue | 1-2 | Pages | 106-10 |
| PubMed ID | 11406278 | Mgi Jnum | J:70054 |
| Mgi Id | MGI:2136124 | Doi | 10.1016/s0167-4781(01)00228-7 |
| Citation | Kohler S, et al. (2001) Analysis of the mouse Scnn1a promoter in cortical collecting duct cells and in transgenic mice. Biochim Biophys Acta 1519(1-2):106-10 |
| abstractText | We have isolated and characterised the promoter of the mouse Scnn1a (alpha ENaC) gene. Using transient transfections of serial deletion mutants into Scnn1a-expressing cells, we demonstrate that 1.56 kb of 5' upstream sequence is required for cell-specific expression and corticosteroid-mediated regulation. These 5' sequences are not sufficient to drive expression of a lacZ reporter gene or a rat Scnn1a cDNA in transgenic mice, where they failed to rescue Scnn1a deficiency. |
