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Protein Coding Gene : Arl13b ADP-ribosylation factor-like 13B
Primary Identifier  MGI:1915396 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  68146
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable GTP binding activity and GTPase activity. Involved in nervous system development; non-motile cilium assembly; and smoothened signaling pathway. Acts upstream of or within dorsal/ventral pattern formation; heart looping; and left/right axis specification. Located in axoneme; ciliary membrane; and motile cilium. Is expressed in several structures, including chordamesoderm; embryo mesenchyme; gonad; neural ectoderm; and node. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Orthologous to human ARL13B (ADP ribosylation factor like GTPase 13B).
PHENOTYPE: Mice homozygous for an ENU-induced mutation die at E13-E14 exhibiting left-right randomization and absence of the floor plate in the caudal spinal cord. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA A930014M17 gene,
  • A530097K21Rik,
  • C530009C10Rik,
  • RIKEN cDNA A530097K21 gene,
  • hennin,
  • Arl2l1,
  • RIKEN cDNA C530009C10 gene,
  • A930014M17Rik,
  • hnn,
  • MGI:3026930,
  • ADP-ribosylation factor-like 2-like 1,
  • Arl13b,
  • ADP-ribosylation factor-like 13B,
  • MGI:3578137,
  • MGI:1925200
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