| First Author | Zhong C | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 2 | Pages | 169-78 |
| PubMed ID | 26595886 | Mgi Jnum | J:259594 |
| Mgi Id | MGI:6141868 | Doi | 10.1038/ni.3318 |
| Citation | Zhong C, et al. (2016) Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment. Nat Immunol 17(2):169-78 |
| abstractText | The transcription factor GATA-3 is indispensable for the development of all innate lymphoid cells (ILCs) that express the interleukin 7 receptor alpha-chain (IL-7Ralpha). However, the function of low GATA-3 expression in committed group 3 ILCs (ILC3 cells) has not been identified. We found that GATA-3 regulated the homeostasis of ILC3 cells by controlling IL-7Ralpha expression. In addition, GATA-3 served a critical function in the development of the NKp46(+) ILC3 subset by regulating the balance between the transcription factors T-bet and RORgammat. Among NKp46(+) ILC3 cells, although GATA-3 positively regulated genes specific to the NKp46(+) ILC3 subset, it negatively regulated genes specific to lymphoid tissue-inducer (LTi) or LTi-like ILC3 cells. Furthermore, GATA-3 was required for IL-22 production in both ILC3 subsets. Thus, despite its low expression, GATA-3 was critical for the homeostasis, development and function of ILC3 subsets. |
