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Publication : Peroxiredoxin 6 is required for blood vessel integrity in wounded skin.

First Author  Kümin A Year  2007
Journal  J Cell Biol Volume  179
Issue  4 Pages  747-60
PubMed ID  18025307 Mgi Jnum  J:135552
Mgi Id  MGI:3794019 Doi  10.1083/jcb.200706090
Citation  Kumin A, et al. (2007) Peroxiredoxin 6 is required for blood vessel integrity in wounded skin. J Cell Biol 179(4):747-60
abstractText  Peroxiredoxin 6 (Prdx6) is a cytoprotective enzyme with largely unknown in vivo functions. Here, we use Prdx6 knockout mice to determine its role in UV protection and wound healing. UV-mediated keratinocyte apoptosis is enhanced in Prdx6-deficient mice. Upon skin injury, we observe a severe hemorrhage in the granulation tissue of knockout animals, which correlates with the extent of oxidative stress. At the ultrastructural level endothelial cells appear highly damaged, and their rate of apoptosis is enhanced. Knock-down of Prdx6 in cultured endothelial cells also increases their susceptibility to oxidative stress, thus confirming the sensitivity of this cell type to loss of Prdx6. Wound healing studies in bone marrow chimeric mice demonstrate that Prdx6-deficient inflammatory and endothelial cells contribute to the hemorrhage phenotype. These results provide insight into the cross-talk between hematopoietic and resident cells at the wound site and the role of reactive oxygen species in this interplay.
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