Primary Identifier | MGI:106657 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 20821 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in positive regulation of viral entry into host cell. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; retina; and thymus primordium. Orthologous to human TRIM21 (tripartite motif containing 21). PHENOTYPE: Mice homozygous for a null allele display reduced survival and abnormal immune responses. Mice homozygous for a second null allele display increased salivation. [provided by MGI curators] |