| Primary Identifier | IPR036822 | Type | Homologous_superfamily |
| Short Name | CutC_dom_sf |
| description | Copper homeostasis protein CutC was originally thought to be involved in copper tolerance in Escherichia coli, as mutation in the corresponding gene lead to an increased copper sensitivity []. However, this phenotype has been later reported to depend on the levels of the mRNA-interfering complementary RNA regulator MicL, which is transcribed from a promoter located within the coding sequence of the cutC gene in the enterobacteria []. In the plant pathogen Xylella fastidiosa, this protein has been reported as specific for copper efflux []. The structure of this protein in the bacteria Shigella flexneri showed a monomer structure that adopts a common TIM β/α barrel with 8 β-strands surrounded by 8 α-helices [].The human homologue of this protein, which structure showed a potential copper-binding site, has an important role in intracellular copper homeostasis [, ]. |
