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Protein Coding Gene : Creb1 cAMP responsive element binding protein 1

Primary Identifier  MGI:88494 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  12912
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in several processes, including cellular response to retinoic acid; protein stabilization; and regulation of lipid biosynthetic process. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; lung development; and nervous system development. Part of ATF4-CREB1 transcription factor complex and chromatin. Is active in nucleus. Is expressed in several structures, including brain; genitourinary system; limb; lung; and maxillary process. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1).
PHENOTYPE: Mice homozygous for alleles lacking some or all isotypes exhibit a range of defects involving circadian rhythms, axonal growth, sensory neuron survival, long-term memory, fear conditioning, body size, respiration, and neonatal viability. [provided by MGI curators]
  • synonyms:
  • expressed sequence AV083133,
  • AV083133,
  • RIKEN cDNA 2310001E10 gene,
  • MGI:1913933,
  • MGD-MRK-2134,
  • cAMP responsive element binding protein 1,
  • MGD-MRK-2136,
  • MGD-MRK-2135,
  • RIKEN cDNA 3526402H21 gene,
  • MGI:1913601,
  • 2310001E10Rik,
  • 3526402H21Rik,
  • Creb-1,
  • MGI:2138519,
  • Creb1,
  • Creb,
  • cyclic AMP responsive element binding protein

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

3 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For