Type | MGI:General | Description | at E12, the cochlear region is wider than normal and displays a stunted ventral extension at E11.5, cochlear outgrowth is arrested due to increased apoptosis of cells in the cochlear anlage; however, apoptosis within the otic epithelia is greatly reduced by E12.5 a rudimentary cochlea is always present in all mutant inner ears the cochlear phenotype is more severe on a 129/Sv genetic background (cochlear agenesis) than on a mixed 129/Sv x C57BL/6 background |