| First Author | Brekken RA | Year | 2014 |
| Journal | Cancer Discov | Volume | 4 |
| Issue | 1 | Pages | 25-6 |
| PubMed ID | 24402944 | Mgi Jnum | J:209157 |
| Mgi Id | MGI:5566566 | Doi | 10.1158/2159-8290.CD-13-0912 |
| Citation | Brekken RA (2014) Faulty ECM signaling facilitates autoimmune lymphomagenesis. Cancer Discov 4(1):25-6 |
| abstractText | The contribution of the extracellular matrix (ECM) to the microenvironment of solid tumors is appreciated although not completely understood; however, the contribution of the ECM to the development of hematopoietic tumors has not been investigated in depth. A new study by Sangaletti and colleagues demonstrates that faulty ECM signaling can facilitate malignant lymphoproliferation in mice predisposed to autoimmunity. Similar changes in ECM construction, consistent with a loss of inhibitory ECM signaling, were identified in the transition from reactive lymphoid hyperplasia to malignant chronic lymphocytic leukemia in patients. These results reveal a critical contribution of reduced collagen signaling in lymphoma and highlight the importance of appropriate ECM construction for maintenance of tissue homeostasis. |
