| First Author | Appelberg R | Year | 2000 |
| Journal | Infect Immun | Volume | 68 |
| Issue | 1 | Pages | 19-23 |
| PubMed ID | 10603363 | Mgi Jnum | J:59108 |
| Mgi Id | MGI:1350908 | Doi | 10.1128/iai.68.1.19-23.2000 |
| Citation | Appelberg R, et al. (2000) Differences in resistance of C57BL/6 and C57BL/10 mice to infection by Mycobacterium avium are independent of gamma interferon. Infect Immun 68(1):19-23 |
| abstractText | After infection with a low-virulence strain of Mycobacterium avium, C57BL/6 and C57BL/10 mice had clear differences in the control of the infection in their livers and spleens. This difference in susceptibility was not associated with differences in the H-2 complex. It was dependent on the activity of CD4(+) T cells but unrelated to the ability of these cells to secrete gamma interferon or to the development of delayed-type hypersensitivity responses at 3 weeks of infection. It was associated with lower total numbers of CD4(+) cells present in infected spleens and was related to an earlier induction of protective T cells, as measured by adoptive-transfer assays. These data further strengthen the notion of gamma-interferon-independent mechanisms of protection against mycobacteria. |
