| First Author | Celli S | Year | 2005 |
| Journal | J Exp Med | Volume | 202 |
| Issue | 9 | Pages | 1271-8 |
| PubMed ID | 16275764 | Mgi Jnum | J:118752 |
| Mgi Id | MGI:3700329 | Doi | 10.1084/jem.20051018 |
| Citation | Celli S, et al. (2005) CD4 T cells integrate signals delivered during successive DC encounters in vivo. J Exp Med 202(9):1271-8 |
| abstractText | The cellular mode of T cell priming in vivo remains to be characterized fully. We investigated the fate of T cell-dendritic cell (DC) interactions in the late phase of T cell activation in the lymph node. In general, CD4 T cells detach from DCs before undergoing cell division. Using a new approach to track the history of antigen (Ag)-recognition events, we demonstrated that activated/divided T cells reengage different DCs in an Ag-specific manner. Two-photon imaging of intact lymph nodes suggested that T cells could establish prolonged interactions with DCs at multiple stages during the activation process. Importantly, signals that are delivered during subsequent DC contacts are integrated by the T cell and promote sustained IL-2Ralpha expression and IFN-gamma production. Thus, repeated encounters with Ag-bearing DCs can occur in vivo and modulate CD4 T cell differentiation programs. |
