| First Author | Brünner N | Year | 1993 |
| Journal | Breast Cancer Res Treat | Volume | 24 |
| Issue | 3 | Pages | 257-64 |
| PubMed ID | 8435480 | Mgi Jnum | J:4994 |
| Mgi Id | MGI:53473 | Doi | 10.1007/BF01833265 |
| Citation | Brunner N, et al. (1993) The nude mouse as an in vivo model for human breast cancer invasion and metastasis. Breast Cancer Res Treat 24(3):257-64 |
| abstractText | Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model. |
