| Primary Identifier | MGI:2686159 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 383619 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including identical protein binding activity; pattern recognition receptor activity; and signaling adaptor activity. Involved in several processes, including AIM2 inflammasome complex assembly; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of defense response. Acts upstream of or within cellular response to interferon-beta. Part of AIM2 inflammasome complex. Is active in cytoplasm; nucleus; and site of double-strand break. Orthologous to human AIM2 (absent in melanoma 2). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit increased susceptibility to bacterial and viral infections with altered cytokine production and inflammatory cell death (pyrotosis). [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
