| First Author | Korets-Smith E | Year | 2004 |
| Journal | Genesis | Volume | 40 |
| Issue | 3 | Pages | 131-8 |
| PubMed ID | 15493019 | Mgi Jnum | J:94203 |
| Mgi Id | MGI:3511612 | Doi | 10.1002/gene.20074 |
| Citation | Korets-Smith E, et al. (2004) Cre recombinase specificity defined by the tau locus. Genesis 40(3):131-8 |
| abstractText | We generated a transgenic mouse line (tau::Cre) by targeting the Cre to the tau locus (Mapt). Based on previous reports on the expression of Tau during development, we expected the Cre recombinase to be expressed in a neuron-specific and pan-neuronal manner. However, intercrosses between the tau::Cre and the Cre-activatable reporter animals resulted in offspring with recombination either restricted to the nervous system or throughout the entire conceptus, indicating expression of Tau early in development. The percentage of neuron-specific excision was dependent on the Cre reporter used representing different Cre target sites in the mouse genome. In spite of the observed variability, our data suggest that the tau::Cre mouse line can be used for pan-neuronal recombination of floxed alleles when it is used with caution. genesis 40:131-138, 2004. (c) 2004 Wiley-Liss, Inc. |
