Primary Identifier | MGI:4839639 | Allele Type | Targeted |
Gene | Adrb1 | Transmission | Germline |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The final serine residue (the third from the end) was mutated to alanine to prohibit PDZ protein (post synaptic density protein (PSD95, Dlg4), Drosophila disc large tumor suppressor (DlgA; Dlg1), and zonula occludens-1 protein (zo-1; Tjp1)) binding. A residual loxP site is located in the 3' UTR after excision of a loxP-flanked neomycin cassette. |