| First Author | Nivoit P | Year | 2023 |
| Journal | Cell Mol Life Sci | Volume | 80 |
| Issue | 8 | Pages | 210 |
| PubMed ID | 37460898 | Mgi Jnum | J:347072 |
| Mgi Id | MGI:7620570 | Doi | 10.1007/s00018-023-04859-9 |
| Citation | Nivoit P, et al. (2023) Autophagy protein 5 controls flow-dependent endothelial functions. Cell Mol Life Sci 80(8):210 |
| abstractText | Dysregulated autophagy is associated with cardiovascular and metabolic diseases, where impaired flow-mediated endothelial cell responses promote cardiovascular risk. The mechanism by which the autophagy machinery regulates endothelial functions is complex. We applied multi-omics approaches and in vitro and in vivo functional assays to decipher the diverse roles of autophagy in endothelial cells. We demonstrate that autophagy regulates VEGF-dependent VEGFR signaling and VEGFR-mediated and flow-mediated eNOS activation. Endothelial ATG5 deficiency in vivo results in selective loss of flow-induced vasodilation in mesenteric arteries and kidneys and increased cerebral and renal vascular resistance in vivo. We found a crucial pathophysiological role for autophagy in endothelial cells in flow-mediated outward arterial remodeling, prevention of neointima formation following wire injury, and recovery after myocardial infarction. Together, these findings unravel a fundamental role of autophagy in endothelial function, linking cell proteostasis to mechanosensing. |
