| Primary Identifier | MGI:5523547 | Allele Type | Transgenic |
| Attribute String | Conditional ready, Inserted expressed sequence | Gene | Tg(Camk2a-HBEGF)BNKza |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A targeting construct contained the Camk2a promoter, a loxp flanked alkaline phosphates-pA stop cassette and the sequence for the human homolog of heparin-binding epidermal growth factor-like growth factor (HBEGF) which functions as a diphtheria toxin receptor (DTR) in mice. Lines A and B were generated with line B exhibiting reduced expression compared with line A. Upon cre-mediated excision of the floxed AP stop cassette, the DTR is expressed making it possible to ablate specific cell populations. |
