| First Author | Yamazaki T | Year | 2002 |
| Journal | J Exp Med | Volume | 195 |
| Issue | 5 | Pages | 535-45 |
| PubMed ID | 11877477 | Mgi Jnum | J:75075 |
| Mgi Id | MGI:2175921 | Doi | 10.1084/jem.20011751 |
| Citation | Yamazaki T, et al. (2002) Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med 195(5):535-45 |
| abstractText | BCAP was recently cloned as a binding molecule to phosphoinositide 3-kinase (PI3K). To investigate the role of BCAP, mutant mice deficient in BCAP were generated. While BCAP-deficient mice are viable, they have decreased numbers of mature B cells and B1 B cell deficiency. The mice produce lower titers of serum immunoglobulin (Ig)M and IgG3, and mount attenuated responses to T cell--independent type II antigen. Upon B cell receptor cross-linking, BCAP-deficient B cells exhibit reduced Ca(2+) mobilization and poor proliferative responses. These findings demonstrate that BCAP plays a pivotal immunoregulatory role in B cell development and humoral immune responses. |
