| First Author | Yamazaki T | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 8 | Pages | 780-6 |
| PubMed ID | 12833156 | Mgi Jnum | J:84669 |
| Mgi Id | MGI:2668807 | Doi | 10.1038/ni949 |
| Citation | Yamazaki T, et al. (2003) Contribution of BCAP to maintenance of mature B cells through c-Rel. Nat Immunol 4(8):780-6 |
| abstractText | Mice deficient in the B cell adaptor for phosphoinositide 3-kinase (BCAP) have reduced numbers of mature B lymphocytes, which show defects in cell survival and proliferation. We found here that the NF-kappa B (Rel) pathway was impaired in BCAP-deficient mature B cells and that NF-kappa B target genes, indispensable for cell survival and division, were not induced in response to B cell receptor (BCR) stimulation. Among the NF-kappa B (Rel) family, expression of c-Rel was specifically reduced in BCAP-deficient B cells. Retrovirus-mediated reintroduction of c-Rel restored the pool size of immunoglobulin (Ig)M(lo)IgD(hi) mature B cells in the spleen as well as proliferative responses to BCR stimulation. These results indicate BCAP is essential in the maintenance of mature B cells through functional coupling with c-Rel. |
