Primary Identifier | MGI:3617379 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Dclk1 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Cre mediated recombination was used to remove exon 3. Removal of this exon is predicted to result in splicing of exon 2 to a downstream exon, resulting in out-of-frame splicing. Exon 3 encodes the majority of the R1 repeat. Mutants demonstrated abolishment of isoforms containing the DCX domain. |