| First Author | Ohkawara S | Year | 2007 |
| Journal | Nutr Cancer | Volume | 59 |
| Issue | 1 | Pages | 92-8 |
| PubMed ID | 17927507 | Mgi Jnum | J:139830 |
| Mgi Id | MGI:3810218 | Doi | 10.1080/01635580701397608 |
| Citation | Ohkawara S, et al. (2007) Effect of oral administration of Butyrivibrio fibrisolvens MDT-1, a gastrointestinal bacterium, on 3-methylcholanthrene-induced tumor in mice. Nutr Cancer 59(1):92-8 |
| abstractText | Butyrivibrio fibrisolvens MDT-1 was evaluated for use as a probiotic to prevent tumor formation. Oral administration of MDT-1 (10(9) cfu/dose, 3 times a wk for 15 wk) delayed the onset of tumors induced by 3-methylcholanthrene and also reduced tumor incidence in mice. Furthermore, the numbers of natural killer (NK) and NKT cells in the spleen increased markedly in response to MDT-1 administration. Increased numbers of NK and NKT cells may contribute to the alleviation of carcinogenesis by MDT-1 administration. Cultured splenic lymphocytes isolated from mice fed MDT-1 produced higher levels of interferon-gamma than control mice but showed no change in interleukin-4 production. These results suggest that MDT-1 administration skews the ratio of helper T (Th) cells type 1 (Th1) to Th2 toward Th1 dominance. MDT-1 administration resulted in increased immunoglobulin A secretion into the intestine. These results suggest that probiotic B. fibrisolvens MDT-1 may contribute to the prevention or alleviation of cancers, allergic disorders, and infectious diseases. |
