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Protein Coding Gene : Mapkapk2 MAP kinase-activated protein kinase 2

Primary Identifier  MGI:109298 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  17164
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables protein serine/threonine kinase activity. Involved in several processes, including macropinocytosis; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2).
PHENOTYPE: Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection. [provided by MGI curators]
  • synonyms:
  • AA960234,
  • MK2,
  • Mapkapk2,
  • MAPKAP kinase 2,
  • MGD-MRK-38343,
  • MGI:2138137,
  • ribosomal protein S6 kinase, 60 kDa, polypeptide 1,
  • Rps6kc1,
  • expressed sequence AA960234,
  • MAP kinase-activated protein kinase 2

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

53 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For