First Author | Horlick RA | Year | 1992 |
Journal | Gene | Volume | 120 |
Issue | 2 | Pages | 291-5 |
PubMed ID | 1398143 | Mgi Jnum | J:60851 |
Mgi Id | MGI:1354004 | Doi | 10.1016/0378-1119(92)90108-2 |
Citation | Horlick RA, et al. (1992) Cloning, expression and tissue distribution of the gene encoding rat fibroblast growth factor receptor subtype 4. Gene 120(2):291-5 |
abstractText | The rat homologue of the gene encoding the fibroblast growth factor receptor subtype 4 (FGFR4) was cloned from rat lung mRNA, and the cDNA sequence was found to be 95% similar and 92% identical to the human homologue. Northern blot analysis of adult rat tissues demonstrated that a 3.1-kb mRNA encoding FGFR4 is detectable only in the lung and kidney. The receptor variant described here encodes two potential immunoglobulin-like domains, 21 hydrophobic amino acids encoding a potential transmembrane domain, and a split tyrosine kinase motif. However, the acidic box and hydrophobic signal peptide domains are not present in this cDNA isolate. |