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Protein Coding Gene : Rps6ka5 ribosomal protein S6 kinase, polypeptide 5

Primary Identifier  MGI:1920336 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  73086
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; regulation of DNA-templated transcription; and regulation of postsynapse organization. Located in nucleus. Orthologous to human RPS6KA5 (ribosomal protein S6 kinase A5).
PHENOTYPE: Mice homozygous for a mutant allele exhibit altered response to cocaine including decreased hyperlocomotor activity and sensitization at a lower dose. Mice homozygous for a kinase dead allele exhibit altered experience-dependent synaptic plasticity. [provided by MGI curators]
  • synonyms:
  • MSK1,
  • MGI:1917998,
  • 6330404E13Rik,
  • expressed sequence AI854034,
  • RIKEN cDNA 3110005L17 gene,
  • Rps6ka5,
  • AI854034,
  • 3110005L17Rik,
  • MGI:2144911,
  • ribosomal protein S6 kinase, polypeptide 5,
  • RIKEN cDNA 6330404E13 gene

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

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0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

36 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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