| First Author | Morris JC | Year | 1996 |
| Journal | Exp Hematol | Volume | 24 |
| Issue | 12 | Pages | 1369-76 |
| PubMed ID | 8913282 | Mgi Jnum | J:36446 |
| Mgi Id | MGI:83872 | Citation | Morris JC, et al. (1996) Molecular cloning and characterization of murine interleukin-11. Exp Hematol 24(12):1369-76 |
| abstractText | Human interleukin-11 (IL-11) has been shown to have pleiotropic action on hematopoietic, hepatic, stromal, epithelial, neural, and osteoclast cells. In the present work, the murine IL-11 cDNA has been isolated from a fetal thymic cell line, and its structure and function compared with human IL-11. The murine protein was demonstrated to have identical actions on the proliferation of a murine plasmacytoma cell line, murine primitive bone marrow progenitor cells, and megakaryocyte precursors. The murine IL-11 protein was synthesized as a soluble thioredoxin-IL-11 fusion in Escherichia coli and the expression of murine IL-11 was examined by pulse-chase radiolabeling in COS cells. The chromosomal location of the murine IL-11 gene was assigned to the proximal arm of chromosome 7. |
