| First Author | Abromson-Leeman S | Year | 2009 |
| Journal | J Neuroimmunol | Volume | 215 |
| Issue | 1-2 | Pages | 10-24 |
| PubMed ID | 19692128 | Mgi Jnum | J:155727 |
| Mgi Id | MGI:4415300 | Doi | 10.1016/j.jneuroim.2009.07.007 |
| Citation | Abromson-Leeman S, et al. (2009) Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. J Neuroimmunol 215(1-2):10-24 |
| abstractText | Th1/Th17 cells, secreting both IFNgamma and IL-17, are often associated with inflammatory pathology. We cloned and studied the cytokine phenotypes of MBP-specific, TCR-identical encephalitogenic CD4+ cells in relationship to Th1- and Th17-associated transcription factors T-bet and RORgammat. IFNgamma-producing cells could be sub-divided into those that are T-bet(+)/RORgammat(-) and those that are T-bet(+)/RORgammat(+). The latter comprises a spectrum of phenotypes, as defined by IL-17 production, and can be induced to up-regulate IL-23R with IL-12 or IL-23. The former, bona fide Th1 cells, lack IL-23R expression under all conditions. In vivo, T-bet(+)/RORgammat(-) and T-bet(+)/RORgammat(+) clones induce EAE equally well. |
