| Primary Identifier | MGI:1353576 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 30955 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of Rac protein signal transduction; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within several processes, including cellular response to cAMP; negative regulation of fibroblast apoptotic process; and regulation of calcium ion transmembrane transport. Predicted to be located in cytosol and membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in hemolymphoid system and thymus primordium. Human ortholog(s) of this gene implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). PHENOTYPE: Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
