| Primary Identifier | MGI:104887 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 14775 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables glutathione peroxidase activity. Involved in arachidonic acid metabolic process. Acts upstream of or within several processes, including angiogenesis involved in wound healing; regulation of intracellular signal transduction; and skeletal muscle fiber development. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); nutritional deficiency disease (multiple); and respiratory system cancer (multiple). Orthologous to human GPX1 (glutathione peroxidase 1). PHENOTYPE: Homozygotes for targeted null mutations show increased sensitivity to the oxidative stress agents paraquat and hydrogen peroxide and to ischemia/reperfusion and cold-induced brain injury. Mutants also show paradoxical bradykinin-induced vasoconstriction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
