| First Author | Drummond HA | Year | 2011 |
| Journal | Am J Physiol Renal Physiol | Volume | 301 |
| Issue | 2 | Pages | F443-9 |
| PubMed ID | 21543417 | Mgi Jnum | J:175287 |
| Mgi Id | MGI:5285067 | Doi | 10.1152/ajprenal.00694.2010 |
| Citation | Drummond HA, et al. (2011) Renal inflammation and elevated blood pressure in a mouse model of reduced {beta}-ENaC. Am J Physiol Renal Physiol 301(2):F443-9 |
| abstractText | Previous studies suggest beta-epithelial Na(+) channel protein (beta-ENaC) may mediate myogenic constriction, a mechanism of blood flow autoregulation. A recent study demonstrated that mice with reduced levels of beta-ENaC (beta-ENaC m/m) have delayed correction of whole kidney blood flow responses, suggesting defective myogenic autoregulatory capacity. Reduced renal autoregulatory capacity is linked to renal inflammation, injury, and hypertension. However, it is unknown whether beta-ENaC m/m mice have any complications associated with reductions in autoregulatory capacity such as renal inflammation, injury, or hypertension. To determine whether the previously observed altered autoregulatory control was associated with indicators of renal injury, we evaluated beta-ENaC m/m mice for signs of renal inflammation and tissue remodeling using marker expression. We found that inflammatory and remodeling markers, such as IL-1beta, IL-6, TNF-alpha, collagen III and transforming growth factor-beta, were significantly upregulated in beta-ENaC m/m mice. To determine whether renal changes were associated with changes in long-term control of blood pressure, we used radiotelemetry and found that 5-day mean arterial blood pressure (MAP) was significantly elevated in beta-ENaC m/m (120 +/- 3 vs. 105 +/- 2 mmHg, P = 0.016). Our findings suggest loss of beta-ENaC is associated with early signs of renal injury and increased MAP. |
