| First Author | Ohinata Y | Year | 2003 |
| Journal | FEBS Lett | Volume | 537 |
| Issue | 1-3 | Pages | 1-5 |
| PubMed ID | 12606021 | Mgi Jnum | J:82340 |
| Mgi Id | MGI:2652309 | Doi | 10.1016/s0014-5793(03)00036-x |
| Citation | Ohinata Y, et al. (2003) A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. FEBS Lett 537(1-3):1-5 |
| abstractText | We report a novel gene Peas that constitutes an overlapping gene complex in mammalian genome. We have cloned human and mouse Peas cDNAs (hPEAS/mPeas) and analyzed their tissue and stage-specific expressions. Peas protein contains six repeated kelch motifs, structurally similar to RAG2, a V(D)J recombination activator, and is evolutionarily conserved among mammals, birds, insects, and nematodes. Northern, RNA in situ hybridization and immunohistochemical analyses showed that mPeas is specifically transcribed in testis, particularly in pachytene spermatocytes in which it is localized to the cytoplasm and meiotic chromatin. It is suggested that Peas may be involved in meiotic recombination process. |
