| Primary Identifier | MGI:6714085 | Allele Type | Targeted |
| Gene | Ccdc6 | Transmission | Germline |
| Strain of Origin | 129 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | An approximate 12 kb genomic region containing exon 2 was replaced with a neomycin-resistance cassette in the opposite transcriptional orientation of the endogenous gene. RT-PCR analysis confirmed the presence of an exon 2 deleted transcript and Western blot shows the expression of a truncated protein. The deletion of exon 2 which contains the coiled-coil domain results in increased CREB1 transcriptional activity. |
