| First Author | Kusakabe T | Year | 2004 |
| Journal | Genesis | Volume | 39 |
| Issue | 3 | Pages | 212-6 |
| PubMed ID | 15282748 | Mgi Jnum | J:92293 |
| Mgi Id | MGI:3052360 | Doi | 10.1002/gene.20043 |
| Citation | Kusakabe T, et al. (2004) Thyrocyte-specific expression of Cre recombinase in transgenic mice. Genesis 39(3):212-6 |
| abstractText | A transgenic mouse line that expresses Cre recombinase under control of the human thyroid peroxidase (TPO) gene promoter was established. The activity and specificity of the TPO-driven Cre recombinase were examined by using Northern blotting and by crossing with the ROSA26 reporter transgenic mouse line. In the latter mice, Cre-mediated recombination occurred only in the thyrocytes, and recombination commenced around embryonic day 14.5, at the time during thyroid organogenesis when TPO expression begins. This study demonstrates that the TPO-Cre transgenic mouse is a powerful tool to specifically delete loxP-inserted (floxed) genes in thyrocytes and will be of great value in the study of thyrocyte-specific genes during development and/or in adult thyroids. |
