| First Author | Silva TM | Year | 2022 |
| Journal | Brain Res | Volume | 1791 |
| Pages | 147995 | PubMed ID | 35779583 |
| Mgi Jnum | J:327608 | Mgi Id | MGI:7329477 |
| Doi | 10.1016/j.brainres.2022.147995 | Citation | Silva TM, et al. (2022) The effect of central growth hormone action on hypoxia ventilatory response in conscious mice. Brain Res 1791:147995 |
| abstractText | Growth hormone (GH)-responsive neurons regulate several homeostatic behaviors including metabolism, energy balance, arousal, and stress response. Therefore, it is possible that GH-responsive neurons play a role in other responses such as CO2/H(+)-dependent breathing behaviors. Here, we investigated whether central GH receptor (GHR) modulates respiratory activity in conscious unrestrained mice. First, we detected clusters of GH-responsive neurons in the tyrosine hydroxylase-expressing cells in the rostroventrolateral medulla (C1 region) and within the locus coeruleus (LC). No significant expression was detected in phox2b-expressing cells in the retrotrapezoid nucleus. Whole body plethysmography revealed a reduction in the tachypneic response to hypoxia (FiO2 = 0.08) without changing baseline breathing and the hypercapnic ventilatory response. Contrary to the physiological findings, we did not find significant differences in the number of fos-activated cells in the nucleus of the solitary tract (NTS), C1, LC and paraventricular nucleus of the hypothalamus (PVH). Our finding suggests a possible secondary role of central GH action in the tachypneic response to hypoxia in conscious mice. |
