| First Author | Aït-Azzouzene D | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 2 | Pages | 939-48 |
| PubMed ID | 16393979 | Mgi Jnum | J:126624 |
| Mgi Id | MGI:3761755 | Doi | 10.4049/jimmunol.176.2.939 |
| Citation | Ait-Azzouzene D, et al. (2006) Split tolerance in peripheral B cell subsets in mice expressing a low level of Igkappa-reactive ligand. J Immunol 176(2):939-48 |
| abstractText | Peripheral B cell tolerance differs from central tolerance in anatomic location, in the stage of B cell development, and in the diversity of Ag-responsive cells. B cells in secondary lymphoid organs are heterogeneous, including numerous subtypes such as B-1, marginal zone, transitional, and follicular B cells, which likely respond differently from one another to ligand encounter. We showed recently that central B cell tolerance mediated by receptor editing was induced in mice carrying high levels of a ubiquitously expressed kappa-macroself Ag, a synthetic superantigen reactive to Igkappa. In this study, we characterize a new transgenic line that has a distinctly lower expression pattern from those described previously; the B cell tolerance phenotype of these mice is characterized by the presence of significant numbers of immature kappa+ B cells in the spleen, the loss of mature follicular and marginal zone B cells, the persistence of kappa+ B-1 cells in the peritoneal cavity, and significant levels of serum IgM,kappa. These findings suggest distinct signaling thresholds for tolerance among peripheral B cell subsets reactive with an identical ligand. |
