| First Author | Doi M | Year | 2004 |
| Journal | Biochem Biophys Res Commun | Volume | 313 |
| Issue | 4 | Pages | 888-93 |
| PubMed ID | 14706625 | Mgi Jnum | J:87465 |
| Mgi Id | MGI:2687160 | Doi | 10.1016/j.bbrc.2003.11.181 |
| Citation | Doi M, et al. (2004) Molecular cloning and characterization of a novel gene, EMILIN-5, and its possible involvement in skeletal development. Biochem Biophys Res Commun 313(4):888-93 |
| abstractText | By analyzing expression profiles of human mesenchymal stem cells incubated in osteogenic supplements, we identified and characterized a novel human cDNA, elastin microfibril interface located protein-5 (EMILIN-5), that is likely to play a significant role in the process of osteogenesis. The deduced EMILIN-5 product consists of 766 amino acids with a cysteine-rich EMI domain at the NH(2) terminus. Western blotting detected EMILIN-5 expression in a variety of osteoblastic cell lines. Immunohistochemistry of mouse embryos 13.5 days post-coitus revealed relatively high levels of EMILIN-5 protein in perichondrium cells of developing limbs. Our findings suggest that the EMILIN-5 gene plays an important role in skeletal development. |
