| First Author | Navarro G | Year | 2016 |
| Journal | Cell Metab | Volume | 23 |
| Issue | 5 | Pages | 837-51 |
| PubMed ID | 27133133 | Mgi Jnum | J:235378 |
| Mgi Id | MGI:5796215 | Doi | 10.1016/j.cmet.2016.03.015 |
| Citation | Navarro G, et al. (2016) Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male. Cell Metab 23(5):837-51 |
| abstractText | Although men with testosterone deficiency are at increased risk for type 2 diabetes (T2D), previous studies have ignored the role of testosterone and the androgen receptor (AR) in pancreatic beta cells. We show that male mice lacking AR in beta cells (betaARKO) exhibit decreased glucose-stimulated insulin secretion (GSIS), leading to glucose intolerance. The AR agonist dihydrotestosterone (DHT) enhances GSIS in cultured male islets, an effect that is abolished in betaARKO(-/y) islets and human islets treated with an AR antagonist. In beta cells, DHT-activated AR is predominantly extranuclear and enhances GSIS by increasing islet cAMP and activating the protein kinase A. In mouse and human islets, the insulinotropic effect of DHT depends on activation of the glucagon-like peptide-1 (GLP-1) receptor, and accordingly, DHT amplifies the incretin effect of GLP-1. This study identifies AR as a novel receptor that enhances beta cell function, a finding with implications for the prevention of T2D in aging men. |
